La cohorte ALCOMEMO permet un suivi longitudinal des patients pris en charge dans le réseau RESALCOG pour des troubles cognitifs sévères liés à l’alcool, , dont le syndrome de Korsakoff. L’objectif est d’améliorer la connaissance de ce trouble : l’évolution des troubles chez des patients pris en charge, les facteurs pronostiques et développer de nouvelles approches thérapeutiques.

Brain 18FDG-PET pattern in patients with alcohol-related cognitive impairment.

Clergue-Duval V, Questel F, Azuar J, Paquet C, Cognat E, Amami J, Queneau M, Dereux A, Barré T, Bellivier F, Farid K, Vorspan F.Eur J Nucl Med Mol Imaging. 2020 Feb;47(2):281-291. doi: 10.1007/s00259-019-04487-1.

The purpose of the study is to describe the pattern of 18FDG-PET abnormalities in patients with CI related to alcohol use disorder. METHODS: Patients admitted to the addiction medicine department of a university hospital in Paris between January 2017 and October 2018 with a confirmed diagnosis of alcohol-related cognitive impairment (ARCI) or Wernicke encephalopathy (WE) were included. …

Cerebrospinal Fluid Biomarkers in Patients With Alcohol Use Disorder and Persistent Cognitive Impairment.

Azuar J, Bouaziz-Amar E, Cognat E, Dumurgier J, Clergue-Duval V, Barré T, Amami J, Hispard E, Bellivier F, Paquet C, Vorspan F, Questel F.Alcohol Clin Exp Res. 2021 Mar;45(3):561-565. doi: 10.1111/acer.14554.

BACKGROUND: Although the clinical presentation of alcohol-related cognitive disorder (ARCD) may resemble that of Alzheimer’s disease (AD), the prognosis and treatment of the 2 diseases are different. Cerebrospinal fluid (CSF) biomarkers (tau, phosphorylated tau, and amyloid β) have high diagnostic accuracy in AD and are currently being used to discriminate between psychiatric disorders and AD, but are not used to diagnose ARCD. The aim of this study was to characterize CSF biomarkers in a homogeneous, cognitively impaired alcohol-dependent population. …

Patients With Severe Alcohol-Related Cognitive Impairment Improve in Flexibility When Abstinence Is Maintained: A Comparative Study With Alzheimer’s Disease.

Clergue-Duval V, Barré T, Cognat E, Brichet AL, Géraud C, Azuar J, Michaud P, Lecallier D, Arfaoui-Geffroy S, Hispard E, Paquet C, Bellivier F, Questel F, Vorspan F; all members of the ResAlCog care network.Front Psychol. 2022 Jul 1;13:936639. doi: 10.3389/fpsyg.2022.936639.

The disease progression of severe alcohol-related cognitive impairment (ARCI) is debated. The aim of this study was to compare the cognitive change of patients with severe ARCI in inpatient setting to that of patients with Alzheimer’s disease (AD). …

Le repérage de facteurs de risque de troubles cognitifs chez les patients présentant un TUS est indispensable pour prévenir les troubles et repérer les patients à risque. Nos travaux portent sur les marqueurs de souffrance cérébrale, en particulier lors du sevrage, et les marqueurs nutritionnels.

Nutritional Status During Inpatient Alcohol Detoxification.

Gautron MA, Questel F, Lejoyeux M, Bellivier F, Vorspan F.Alcohol Alcohol. 2018 Jan 1;53(1):64-70. doi: 10.1093/alcalc/agx086.

AIMS: As low rates of thiamine are thought to be implicated in alcohol-related cognitive disorders, we wanted to assess patients with alcohol use disorders (AUD) during detoxification for their nutritional status and test if vitamins blood levels were associated with a surrogate of cognitive impairment. …

Ascorbic Acid Deficiency Prevalence and Associated Cognitive Impairment in Alcohol Detoxification Inpatients: A Pilot Study.

Clergue-Duval V, Azuar J, Fonsart J, Delage C, Rollet D, Amami J, Frapsauce A, Gautron MA, Hispard E, Bellivier F, Bloch V, Laplanche JL, Questel F, Vorspan F. Antioxidants (Basel). 2021 Nov 26;10(12):1892. doi: 10.3390/antiox10121892.

Malnutrition has been reported in alcohol use disorder patients as having a possible influence on cognitive function. The aim of this study was to analyse the prevalence of ascorbic acid (AA) deficiency in inpatients admitted for alcohol detoxification and the associated factors, including cognitive impairment in the early period of abstinence. A retrospective chart review was conducted. … 

Alcohol Withdrawal Is an Oxidative Stress Challenge for the Brain: Does It Pave the Way toward Severe Alcohol-Related Cognitive Impairment?

Clergue-Duval V, Coulbault L, Questel F, Cabé N, Laniepce A, Delage C, Boudehent C, Bloch V, Segobin S, Naassila M, Pitel AL, Vorspan F. Antioxidants (Basel). 2022 Oct 21;11(10):2078. doi: 10.3390/antiox11102078.

Patients with severe alcohol use disorders (AUD) associated with pharmacological dependence suffer from repetitive events of alcohol withdrawal (AW). If those AW are not managed by adequate medical and pharmacological treatment, they may evolve into severe AW, or be complicated by epileptic seizure or delirium tremens (DT). In addition, we suggest that AW favors the occurrence of Wernicke’s encephalopathy (WE) in patients with known or unknown thiamine depletion. We reviewed the literature on oxidative stress as a core mechanism in brain suffering linked with those conditions: AW, epileptic seizure, DT and WE. Thus, we propose perspectives to further develop research projects aiming at better identifying oxidative stress brain damage related to AW, assessing the effect of repetitive episodes of AW, and their long-term cognitive consequences. …

Plasma tau, NfL, GFAP and UCHL1 as candidate biomarkers of alcohol withdrawal-associated brain damage: A pilot study.

Clergue-Duval V, Vrillon A, Jeanblanc J, Questel F, Azuar J, Fouquet G, Mouton-Liger F, Rollet D, Hispard E, Bouaziz-Amar E, Bloch V, Dereux A, Cognat E, Marie-Claire C, Laplanche JL, Bellivier F, Paquet C, Naassila M, Vorspan F.Addict Biol. 2022 Nov;27(6):e13232. doi: 10.1111/adb.13232.

In this translational study, we investigated the plasma tau protein, neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP) and ubiquitin carboxy-terminal hydrolase L1 (UCHL1), which are established biomarkers of neurological injury, as predictive biomarkers of alcohol withdrawal-associated brain toxicity. In the clinical study, patients with severe alcohol use disorder (AUD) on D1 of hospitalization for alcohol cessation (AC) (N = 36) were compared to severe AUD patients with at least 3 months of abstinence (N = 16). …

Predictive factors of cognitive impairment in alcohol use disorder inpatients.

Gautron MA, Clergue-Duval V, Chantre J, Lejoyeux M, Geoffroy PA.Addict Behav. 2024 Nov;158:108132. doi: 10.1016/j.addbeh.2024.108132.

Cognitive impairments are common in patients with AUD and worsen the prognosis of addiction management. There are no clear guidelines for screening cognitive impairments in hospitalized patients with AUD. METHODS : Fifty-seven patients with an AUD history who were admitted to an acute hospital and assessed by the addiction care team were included. Those patients were screened for cognitive impairments using the Montreal Cognitive Assessment (MoCA) test. We collected clinical information regarding addiction history, comorbidities, and current treatments. Chi-square tests, t-tests, and Mann-Whitney tests were performed to determine factors associated with a pathological MoCA score (<26). …